Acetylcysteine Impurity 46 Trifluoroacetic acid CAS 282727-77-9(Free Base)
| CAS No. | 282727-77-9(Free Base) |
| Molecular Formula | C5H9NO5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Acetylcysteine Impurity 46 Trifluoroacetic acid (CAS 282727-77-9(Free Base), C5H9NO5SC2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C5H9NO5SC2HF3O2, Acetylcysteine Impurity 46 Trifluoroacetic acid contains a carbohydrate-derived structure, an amide group, a sulfone group, fluorine substitution; these features give the compound characteristic functional-group stretching vibrations in infrared spectroscopy. The molecular weight of 309.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H9NO5S C2HF3O2 |
| Molecular Weight | 309.21 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Acetylcysteine Standards
- Acetylcysteine Impurity 12 (CAS 1115-65-7)
- Acetylcysteine Impurity 41 (CAS 13100-82-8)
- N-Acetylcysteine-d3 (CAS 131685-11-5)
- Acetylcysteine Impurity 33 (CAS 15058-19-2)
- Acetylcysteine Impurity 37 (CAS 155172-79-5)
- Acetylcysteine Impurity 18 (CAS 1637-71-4)
- Acetylcysteine impurity 66 (CAS 16708-09-1)
- Acetylcysteine EP Impurity D (CAS 18725-37-6)
Recommended Standards
- Ixazomib Impurity 76 (CAS CATO-C4X-126776)
- Tadalafil Impurity 113 (CAS 68807-89-6)
- Ranitidine Impurity 20 (CAS 82301-45-9)
- Ethyl 3,4,6-tri-O-Acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside (CAS 99409-32-2)
- N1,N4-Bis((pyridin-4-yl)-methylene)benzene-1,4-diamine (CAS 78808-21-6)
- 1-(2,4-Dimethyl-1H-pyrrol-3-yl)ethan-1-one (CAS 2386-25-6)
- methyl 4-(1-methyl-1H-pyrazol-3-yl)-2,4-dioxobutanoate (CAS 875553-41-6)
- N-(2-Bromo-4-methylphenyl)-2-ethoxybenzamide (CAS 314022-94-1)
- Sapropterin Hydrochloride (CAS 69056-38-8)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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